S1017-854620040001 Revista Médica del Hospital Nacional de Niños Dr. Carlos Sáenz Herrera Rev. méd. Hosp. Nac. Niños (Costa Rica) 1017-8546 Editorial Nacional de Salud y Seguridad Social S1017-85462004000100001 Síndrome de activación del macrófago Porras Madrigal Oscar ,Caja Costarricense de Seguro Social Hospital Nacional de Niños Dr. Carlos Sáenz Herrera 2004 2004 39 05 11

El síndrome de activación del macrófago (SAM) en un proceso inflamatorio secundario a una activación del sistema mononuclear fagocítico, con proliferación de histiocitos y hemofagocitosis (HF). Se caracteriza por pancitopenia, insuficiencia hepática, coagulopatía y síntomas neurológicos. Es causado por la activación y proliferación sin control de linfocitos T y de macrófagos, que llevan a una sobreproducción de citoquinas. Se han descrito una forma primaria o familiar y una secundaria asociada a infección y enfermedades reumáticas principalmente (10) La característica más frecuente del síndrome es la presencia en médula ósea o tejidos de hemofagocitosis. Los estudios de laboratorio muestran citopenias, hipertrigliceridemia, aumento en la ferritina y una coagulopatía con hipofibrinogenemia. El tratamiento usual en el cuadro agudo es terapia con pulsos de metilprednisolona

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S1017-854620040001 Revista Médica del Hospital Nacional de Niños Dr. Carlos Sáenz Herrera Rev. méd. Hosp. Nac. Niños (Costa Rica) 1017-8546 Editorial Nacional de Salud y Seguridad Social S1017-85462004000100002 Alergia al látex: Una revisión Porras Madrigal Oscar ,Hospital Nacional de Niños Dr. Carlos Sáenz Herrera San José Costa Rica 2004 2004 39 12 23

La alergia al látex de hule natural, se ha convertido en un problema importante de salud en los trabajadores de la salud y en pacientes con espina bífida e intervenciones quirúrgicas múltiples. El tratamiento curativo con inmunoterapia no produce una solución al problema.Las medidas preventivas permiten reducir la incidencia de la alergia al látex y son una mejor estrategia para intervenir en este problema de salud pública. Con el objetivo de aumentar el conocimiento sobre el problema de alergia al látex, discutimos los aspectos relacionados con historia, epidemiología, diagnóstico, prevención y tratamiento. Se definen los términos sensibilización y alergia y se describen los aspectos químicos del látex de hule natural y de sus proteínas. La definición de grupos de riesgo permite desarrollar una estrategia en las intituciones de salud que disminuye la exposición y como consecuencia las manifestaciones clínicas de los individuos sensibilizados

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S1017-854620040001 Revista Médica del Hospital Nacional de Niños Dr. Carlos Sáenz Herrera Rev. méd. Hosp. Nac. Niños (Costa Rica) 1017-8546 Editorial Nacional de Salud y Seguridad Social S1017-85462004000100004 Dengue: Una enfermedad que vino para quedarse Ávila Agüero María L ,Caja Costarricense de Seguro Social Hospital Nacional de Niños Dr. Carlos Sáenz Herrera San José Costa Rica 2004 2004 39 34 41 Dengue fever in Costa Rica and Venezuela Epidemiol. Bull 1990 11 Dengue hemorrhagic fever in Costa Rica and Panama Epidemiol Bull 1994 15 Dengue y dengue hemorrágico en las Américas: Guías para su prevención y control Dengue y dengue hemorrágico en las Américas: Guías para su prevención y control 1997 548 Washington, DC Organización Panamericana de la Salud Bhamarapravati N Yoksan S Gubler D Kuno G Live Attenuated Tetravalent Dengue Vaccine Live Attenuated Tetravalent Dengue Vaccine 1997 London CAB International Bravo J Kouri G Guzman M Why dengue hemorrhagic fever in Cuba?: I. 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S1017-854620040001 Revista Médica del Hospital Nacional de Niños Dr. Carlos Sáenz Herrera Rev. méd. Hosp. Nac. Niños (Costa Rica) 1017-8546 Editorial Nacional de Salud y Seguridad Social S1017-85462004000100005 Epidemiología del asma en Costa Rica Soto-Martínez Manuel Soto-Quirós Manuel ,Caja Costarricense de Seguro Social Hospital Nacional de Niños Dr. Carlos Sáenz Herrera San José Costa Rica 2004 2004 39 42 53 Avila L Soto-Martinez M Soto-Quiros M Prevalencia de asma y otras enfermedades alérgicas en una población de universitarios en Costa Rica Prevalencia de asma y otras enfermedades alérgicas en una población de universitarios en Costa Rica Bejarano J El consumo de tabaco en la población joven costarricense: Hallazgos de la encuesta mundial sobre tabaco en jóvenes (G.Y.T.S, 1999) Revista Costarricense de Salud Publica 2001 18 Celedón J Soto-Quiros M Hanson L Weiss S The relation among markers of allergy, asthma, allergic rhinitis, and eczema in Costa Rica Pediatr. Allergy Immunol 2002 Celedón J Soto-Quiros M Palmer L Lack of association between a polymorphism in the IL-13 gene and total serum IgE among nuclear families in Costa Rica Clin. Experim. Allergy 2002 32 Celedón J Soto-Quiros M Silverman E Risk factors for childhood asthma in Costa Rica Chest 2001 120 Mallol J Direceu S Asher I Prevalence of asthma Symptoms in Latin América: The International Study of Asthma and Allergies in Childhood (ISAAC) Ped. Pulmonol 2000 30 6 Soto Quirós M Belin L Gutiérrez I Allergen sensitization of asthmatic school Children's in Costa Rica Allergy 1998 53 Soto Quirós M Bustamante M Gutiérrez I Hanson L The prevalence of childhood asthma in Costa Rica Clinical and Experimental Allergy 1994 24 Soto Quirós M Sánchez F Factores asociados al asma en Costa Rica: A propósito de un estudio epidemiológico Revista Mexicana de Pediatría 1996 63 Soto Quirós M Stahl A Calderón O Guanine, mite, and cockroach allergens in Costa Rican homes Allergy 1998 53 Soto-Quiros M Studies of the prevalence of asthma and allergy in Costa Rican Children Studies of the prevalence of asthma and allergy in Costa Rican Children 2000 Soto-Quiros M Silverman E Hanson L Maternal history, sensitization to allergens, and current wheezing, rhinitis, and eczema among children in Costa Rica Pediatr. Pulm 2002 33 Soto-Quiros M Soto-Martinez M Hanson L Epidemiological studies of the very high prevalence of asthma and related symptoms among school children in Costa Rica from 1989 to 1998 Pediatr. Allergy. Immunol 2002 13 Soto-Quiros M Soto-Martinez M Hanson L The high prevalence of rhinitis, rhinoconjunctivitis and eczema in Costa Rican school children studied with the ISAAC protocol Pediatric Asthma Allergy Immunology 2004 17
S1017-854620040001 Revista Médica del Hospital Nacional de Niños Dr. Carlos Sáenz Herrera Rev. méd. Hosp. Nac. Niños (Costa Rica) 1017-8546 Editorial Nacional de Salud y Seguridad Social S1017-85462004000100006 Manejo práctico de las neumonías en niños Solano Marcia Soto-Quirós Manuel E ,Caja Costarricense de Seguro Social Hospital Nacional de Niños Dr. Carlos Sáenz Herrera San José Costa Rica 2004 2004 39 54 60 Benguigui Y López F Schuminis G Infecciones Respiratorias en niños Infecciones Respiratorias en niños 1997 ^eWashington DC EUA Hilton S Edward D Practical Pediatric Radiology Practical Pediatric Radiology 1994 2da EUA Pneumococcal vaccine for children Pediatrics and Child Health 2002 6 Nelson J Community-Acquired pneumonia in children: Guidelines for treatment Pediatric Infectious iseases 2000 18 Pelton S Klein J The future of Pneumococcal Conjugate Vaccines for prevention of pneumococcal diseases in infants and children Pediatrics 2002 110 Peter G Hall C Halsey N RED BOOK: Enfermedades Infecciosas en Pediatría RED BOOK: Enfermedades Infecciosas en Pediatría 1998 24 Illinois Rocholl C Gerber C Daly J Adenoviral Infections in children: The Impact of Rapid Diagnosis Pediatrics 2004 113 Schidlow D Callahan C Pneumonia Pediatrics in Review 1996 17 Tan T Mason E Wald E Clinical Characteristics of children with complicated pneumonia caused by Streptococcus pneumoniae Pediatrics 2002 110 Wubbel L Muñiz L Ahmed A Etiology and treatment of community-acquired pneumonia in ambulatory children Pediatr. Infect. Dis. J 1999 18
S1017-854620040001 Revista Médica del Hospital Nacional de Niños Dr. Carlos Sáenz Herrera Rev. méd. Hosp. Nac. Niños (Costa Rica) 1017-8546 Editorial Nacional de Salud y Seguridad Social S1017-85462004000100007 Interpretación de las pruebas de sensibilidad antimicrobiana Herrera Hidalgo Marco Luis ,Caja Costarricense de Seguro Social Laboratorio Clínico Hospital Nacional de Niños San José Costa Rica 2004 2004 39 61 65 Hindler J Swenson J Baron Ellen J Susceptibility testing of fastidious bacteria Susceptibility testing of fastidious bacteria 1999 7th ^eWashington D.C American Society for Microbiology Jorgensen J Turnidge H Washington J Murray Patrick Baron Ellen J Antibacterial Susceptibility Test: Dilution and disk diffusion methods Antibacterial Susceptibility Test: Dilution and disk diffusion methods 1999 7th ^eWashington D.C American Society for Microbiology Performance Standards for Antimicrobial Disk Susceptibility Test: Approved standard M2-A6 Performance Standards for Antimicrobial Disk Susceptibility Test: Approved standard M2-A6 1997 National Committee for Clinical Laboratory StandardsWayne, PA National Committee for Clinical Laboratory Standard Development of In Vitro Susceptibility Testing Criteria and Quality Control Parameters: Tentative Guideline M23-T3 National Committee for Clinical Laboratory Standard Development of In Vitro Susceptibility Testing Criteria and Quality Control Parameters: Tentative Guideline M23-T3 1998 National Committee for Clinical Laboratory StandardsWayne, PA Turnidge H Jorgensen J Murray Patrick Baron Ellen J Antimicrobial susceptibility testing: General Considerations Antimicrobial susceptibility testing: General Considerations 1999 7th ^eWashington D.C American Society for Microbiology
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