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<front>
<journal-meta>
<journal-id pub-id-type="pid">S1409-414220020003</journal-id>
<journal-title>Revista Costarricense de Cardiología</journal-title>
<abbrev-journal-title>Rev. costarric. cardiol</abbrev-journal-title>
<issn>1409-4142</issn>
<publisher>
<publisher-name>Asociación Costarricense de Cardiología</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1409-41422002000300001</article-id>
<title-group>
<article-title xml:lang=""></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Speranza Sánchez</surname>
<given-names>Mario O.</given-names>
</name>
</contrib>
</contrib-group>
<aff id="A">
<institution>,  </institution>
<addr-line> </addr-line>
</aff>
<pub-date pub-type="pub">
<month>12</month>
<year>2002</year>
</pub-date>
<pub-date pub-type="epub">
<year>2002</year>
</pub-date>
<volume>4</volume>
<fpage>03</fpage>
<lpage>03</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http:/www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1409-41422002000300001&amp;lng=en&amp;nrm=iso&amp;tlng=en"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1409-41422002000300001&amp;lng=en&amp;nrm=iso&amp;tlng=en"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1409-41422002000300001&amp;lng=en&amp;nrm=iso"></self-uri></article-meta>
</front>
</article>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id pub-id-type="pid">S1409-414220020003</journal-id>
<journal-title>Revista Costarricense de Cardiología</journal-title>
<abbrev-journal-title>Rev. costarric. cardiol</abbrev-journal-title>
<issn>1409-4142</issn>
<publisher>
<publisher-name>Asociación Costarricense de Cardiología</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1409-41422002000300002</article-id>
<title-group>
<article-title xml:lang="es">Estudio de factores trombogénicos en pacientes menores de 45 años con infarto del miocardio</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Chavez B</surname>
<given-names>Liliana</given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Solazar</surname>
<given-names>Lisbeth</given-names>
</name>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Brilla S</surname>
<given-names>Alfredo</given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Herrmann</surname>
<given-names>F H.</given-names>
</name>
<xref ref-type="aff" rid="A03"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution>,CCSS Hospital San Juan de Dios Servicio de Cardiología</institution>
<addr-line>San José </addr-line>
<country>Costa Rica</country>
</aff>
<aff id="A02">
<institution>,Universidad de Costa Rica Centro de Hemoglobinas Anormales y Trastornos Afines </institution>
<addr-line> </addr-line>
</aff>
<aff id="A03">
<institution>,Institut Für Human Genetic  </institution>
<addr-line>Greifswold </addr-line>
<country>Alemania</country>
</aff>
<pub-date pub-type="pub">
<month>12</month>
<year>2002</year>
</pub-date>
<pub-date pub-type="epub">
<year>2002</year>
</pub-date>
<volume>4</volume>
<fpage>05</fpage>
<lpage>10</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http:/www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1409-41422002000300002&amp;lng=en&amp;nrm=iso&amp;tlng=en"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1409-41422002000300002&amp;lng=en&amp;nrm=iso&amp;tlng=en"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1409-41422002000300002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p>Introducción: El estudio se orientó a buscar trombofílias en pacientes jóvenes con infarto del miocardio tanto genéticas, como las de las proteínas anticoagulantes. Material y Métodos: Las pruebas de laboratorio que se usaron para la medición del fibrinógeno fue el método de Clauss, para la proteína C y Antitrombina III (ATIII) se utilizó un método cromogénico, para la S un método coagulométrico y las pruebas genéticas por Reacción de Cadena Polimerasa (PCR). Se seleccionaron 51 pacientes jóvenes menores de 45 años con infarto agudo del miocardio y 43 pacientes sanos de grupo control de las mismas edades. Resultados: Se encontró un 85% de pacientes masculinos y 15% femeninos. Las variables que fueron factores de riesgo estadísticamente significativas fueron el sexo P = 0.0023 demostrando que por cada 4.19 hombres que sufren infarto existe una mujer. El índice de masa corporal fue significativamente mayor en los pacientes infartados con un valor de P = 0.002733 y existió asociación estadísticamente significativa con obstrucciones coronarias. La hipertensión también fue estadísticamente significativa valor de P = 0.00167. Para el nivel de colesterol total la media en los pacientes sanos fue de 166mg/dl contra 213mg/dl en los pacientes con infarto con un valor de P =0.000527mg/dl. Para el HDL colesterol el 78% de los pacientes infartados tenían niveles iguales o menores de 35mg/dl y existió asociación estadísticamente significativa con la presencia de obstrucciones coronarias. El nivel de triglicéridos mostró una asociación estadísticamente significativa con un valor de P = 0.000161 mg/dl. El 58 % de los pacientes infartados tenían un nivel elevado de LDL colesterol. En el análisis de las proteínas anticoagulantes la población enferma tuvo niveles significativamente menores que el grupo control tanto para la proteína S y la C. En el análisis de los cruces hay una asociación estadísticamente significativa entre la frecuencia alélica de la mutación de la enzima metiltetrahidrofolato reductasa y tener niveles menores de las proteínas C y S tanto en los pacientes enfermos como en los sanos que son homocigotas a la mutación. No hubo asociación estadísticamente significativa para el factor V Leyden y la variable 20210 de Protrombina. Conclusión: En los pacientes menores de 45 años con Infarto del Miocardio existen claros marcadores de riesgo para enfermedad coronaria al compararlos con sujetos sanos de una edad similar.</p></abstract>
<abstract abstract-type="short" xml:lang="en"><p>lntroduction: The study was orientated towards finding thrombophylia in young patients with genetic myocardium infarct as with anticoagulant proteins. Material and Methods: The lab Test used for the fibrinogen was the Clauss Method, for the C protein and ATIII a chromogenic method was used, for the S protein a coagulometrical method and for the genetic testing, PCR. Fifty one young patients were chosen (under 45 years of age) with acute myocardium infarct and 43 healthy patients in the control group in the same age range. Results: An 85% of the patients were male and 15% female. The variable that was a statistically significant risk factor was the gender (P= 0.0023) showing that for every 4.19 men that suffer an infarct there is one woman. The body mass index was substantially higher with infarcted patients (P=0.002733) which had a statistical significant association with coronary obstructions. Hypertension was also statistically significant (P = 0.00167). Mean value for total cholesterol was 166mg/dl in healthy patients versus 213mg/dl with infarcted patients (P = 0.000527mg/dl). A 78% of patients with infarct had HDL cholesterol levels of 35mg/dl or lower and showed a statistically significant association with coronary obstructions. Triglycerides levels also showed a statistically significant association (P= 0.0001 61 mg/dl). A 58% of patients with infarct showed high levels of LDL cholesterol. The analysis of anticoagulant proteins in the sick group resulted in lower levels of S and C versus the control group. Analyzing the crosses, there is a statistically significant association between the allelic frequencies in the mutation of the MTHFR enzyme and having normal levels of C and S protein in the healthy as well as in the control group. There was no statistical significant association in the for the Leyden V factor and the 20210 prothrombin factor variable.</p></abstract>
<kwd-group>
<kwd>Trombosis</kwd>
<kwd>infarto</kwd>
<kwd>proteínas anticoagulantes y factores genéticos</kwd>
<kwd>Thrombosis</kwd>
<kwd>infarct</kwd>
<kwd>anticoagulant proteins and genetic factors</kwd>
</kwd-group>
</article-meta>
</front>
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<self-uri xlink:href="http:/www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1409-41422002000300003&amp;lng=en&amp;nrm=iso&amp;tlng=en"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1409-41422002000300003&amp;lng=en&amp;nrm=iso&amp;tlng=en"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1409-41422002000300003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p>Introducción: Se trata de un procedimiento diferente al tradicional, el cirujano no usa la máquina Corazón-Pulmón o de circulación extracorpórea durante el mismo, en su lugar se usan instrumentos para estabilizar el área destinada para colocar el injerto coronario. Esto permite continuar con el flujo de sangre coronario natural, sin interrupción. Material y Métodos: En la Unidad de Cirugía Cardiovascular de Guatemala &quot;UNICAR&quot; de Agosto de 1999 a Septiembre 2002, 71 pacientes fueron operados de revascularización coronaria con éste método con edades comprendidas entre 35 y 80 años, siendo más frecuente el grupo de 51 a 55 años. Resultados: El porcentaje de Hemoductos realizados por paciente fue de 1.7%, utilizándose en todos Arteria Mamaria Interna para revascularizar la arteria descendente anterior. Se utilizó Arteria Radial en 4 casos. El promedio de estancia en cuidado intensivo fue de 24 horas en el 72%. En el 82% no hubo ninguna complicación, 2 pacientes presentaron derrame pleural (2.81%). Siete pacientes (9.85%) presentaron fallo cardiaco que resolvió en las primeras 48 horas. Un paciente desarrolló Infarto del Miocardio trans-operatorio sin ninguna repercusión hemodinámica (1.4%). La mortalidad fue del 2.85% (2 pacientes) que desarrollaron uno neumonía postoperatoria y el segundo hizo fallo multisistémico por sepsis de causas no cardíacas. Conclusiones: La Revascularización Coronaria sin Circulación Extracorpórea reduce el trauma del músculo cardíaco y órganos blandos. La recuperación es rápida y disminuye la estadía hospitalaria. Reduce el riesgo de sangrado, accidente cerebrovascular y fallo renal. Reduce los problemas psicomotores y cognositivos que se presentan en el método tradicional, la morbi-mortalidad es baja.</p></abstract>
<abstract abstract-type="short" xml:lang="en"><p>lntroduction: Beating heart Bypass is different from tradicional bypass surgery because is performed while the heart continues with his beating. The surgeons do not use the heart-fung machine, or cardiopulmonary bypass. Methods: In the Department of Cardiovascular Surgery in Guatemala, during the period from August 1999 to September 2002, seventy one patients underwent to coronary bypass grafting, beating heart. The median age was 57 years (range from 35 to 80). The range mostly affected was from 51 to 55 years. Results: A mean of 1.70% grafts per patients was performed. The left internar Mammary Artery graft used for left anterior descending artery in 100%. The Radial Artery was used in 4 cases. The length of Intensive care staying was 24 hours (72%). Mortality is 2.85% (2 patients). 1 patient died due pneumonia in 72 hours after surgery. 1 patient died due septicemia in 2 weeks after coronary bypass surgery. Conclusion: Reduce trauma. Quickly recovery and decreased of hospital staying. Reduce risk of bleeding, stroke and renal failure. Reduce psychomotor cognitive problems.</p></abstract>
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<surname>Esquivel Alfaro</surname>
<given-names>Lidieth</given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution>,CCSS Hospital México Servicio de Cardiología</institution>
<addr-line>San José </addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<month>12</month>
<year>2002</year>
</pub-date>
<pub-date pub-type="epub">
<year>2002</year>
</pub-date>
<volume>4</volume>
<fpage>15</fpage>
<lpage>20</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http:/www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1409-41422002000300004&amp;lng=en&amp;nrm=iso&amp;tlng=en"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1409-41422002000300004&amp;lng=en&amp;nrm=iso&amp;tlng=en"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1409-41422002000300004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p>Introducción: Las lesiones obstructivas por arterioesclerosis coronaria genera diversos síndromes coronarios. Sin embargo, un subgrupo de pacientes con angina de pecho y alteraciones electrocardiográficas no presenta dichas lesiones, en el que se incluyen el vasoespasmo coronario, la angina microvascular, los puentes musculares y otras condiciones. En este estudio se evaluaron las principales características clínicas y electrocardiográficas de este grupo de pacientes. Material y métodos: Se incluyeron pacientes con cualquier síndrome coronario y angiografía coronaria sin lesiones obstructivas. Se consignaron los factores de riesgo cardiovascular, los síntomas de presentación, alteraciones electrocardiográficas y ecocardiográficas y los fármacos utilizados. Resultados: Se reclutaron 26 casos, 13 hombres y 13 mujeres con edad promedio de 56.6 años (rango 16 - 78). Se presentó angina microvascular en 16 casos, vasoespasmo coronario en 8, uno con un puente coronario y uno con flujo lento. Como síntomas se observó disnea en 18 pacientes, angor típico en 19 y angor atípico en 7. El electrocardiograma de reposo fue anormal en 18 pacientes, y el de esfuerzo en 13 casos. De 19 ecocardiogramas, 9 fueron anormales. Los fármacos más utilizados fueron los betabloqueadores, los bloqueadores de los canales del calcio y los nitratos. Conclusiones: Los pacientes con síndromes coronarios y angiografía coronaria sin lesiones obstructivas presentan frecuentemente factores de riesgo coronario, no hay diferencia de género y los exámenes auxiliares son anormales lo que motiva la realización de la angiografía.</p></abstract>
<abstract abstract-type="short" xml:lang="en"><p>lntroduction: Coronary arteriosclerosis lesions induce several coronary syndromes. Some patients suffer angina pectoris with abnormal electrocardiograms with no obstructive plaques in the angiogram. This group includes coronary vasospasm, micro vascular angina, muscle bridges and others. This study evaluates the most important clinical and electrocardiograghic findings among this group of patients. Material and Methods: Patients with coronary syndromes and normal coronary angiogram were included. Cardiovascular risk factors were assessed also clinical presentation, electrocardiographic and echocardiographic findings and most frequently used drugs in the hospital. Results: 26 patients were included, 13 male and 13 female with a mean age of 56.6 years (range 16-78). Micro vascular angina was present in 16 cases, coronary spasm in 8, one patient with Muscle Bridge and one with coronary slow flow. Symptoms included dyspnea in 18 patients, typical angina in 19 and atypical angina in 7. electrocardiogram at rest was abnormal in 18 patients. From 9 echocardiographic studies, 9 were abnormal. Drugs most frequentiy used inciuded betablockers, calcium channel blockers and nitrates. Conclusions: Patients with angina and normal coronary angiogram frequently have cardiovascular risk factors, there was no difference regarding gender and ancillary studies were abnormal indicating the coronary angiographic procedure.</p></abstract>
<kwd-group>
<kwd>Angina de pecho</kwd>
<kwd>Coronarias angiográficamente normales</kwd>
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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id pub-id-type="pid">S1409-414220020003</journal-id>
<journal-title>Revista Costarricense de Cardiología</journal-title>
<abbrev-journal-title>Rev. costarric. cardiol</abbrev-journal-title>
<issn>1409-4142</issn>
<publisher>
<publisher-name>Asociación Costarricense de Cardiología</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1409-41422002000300005</article-id>
<title-group>
<article-title xml:lang="es">Primera experiencia en el uso de Cardioplejia sanguínea: estudio prospectivo de 200 casos sometidos a Cirugía Cardíaca en el Hospital México, San José, Costa Rica</article-title>
</title-group>
<contrib-group>
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<surname>Méndez</surname>
<given-names>Edgar A.</given-names>
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<name>
<surname>Segura Ten</surname>
<given-names>Gabriela</given-names>
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<name>
<surname>Zamora Rojas</surname>
<given-names>Fernando</given-names>
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<aff id="A01">
<institution>,CCSS Hospital México </institution>
<addr-line> </addr-line>
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<aff id="A02">
<institution>,CCSS Hospital México </institution>
<addr-line>San José </addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<month>12</month>
<year>2002</year>
</pub-date>
<pub-date pub-type="epub">
<year>2002</year>
</pub-date>
<volume>4</volume>
<fpage>21</fpage>
<lpage>27</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http:/www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1409-41422002000300005&amp;lng=en&amp;nrm=iso&amp;tlng=en"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1409-41422002000300005&amp;lng=en&amp;nrm=iso&amp;tlng=en"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1409-41422002000300005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p>Introducción: Este estudio reporta la primera experiencia del uso de cardioplejia sanguínea durante la cirugía cardíaca en el hospital México y expone la importancia de su uso en cirugía cardíaca. Material y Métodos: Se estudiaron prospectivamente 200 pacientes consecutivos programados a varios procedimientos quirúrgicos cardíacos con el uso de cardioplejia sanguínea en un período comprendido entre setiembre de 1999 y febrero del 2002. Resultados: Estos 200 casos consistieron de 122 hombres y 78 mujeres con una edad promedio de 57.48 años ( rango, 26 a 28 años ). 71 pacientes salieron del arresto cardíaco con ritmo espontáneo. Doce pacientes fallecieron y 30 casos presentaron complicaciones en el postoperatorio: 9 pacientes presentaron infarto agudo al miocardio perioperatorio, 6 casos presentaron para cardiorrespiratorio, 12 tuvieron arritmias cardíacas, 3 pacientes presentaron insuficiencia cardíaca congestivo. Conclusiones: En esta experiencia preliminar, el uso de la cardioplejia sanguínea parece proveer una protección miocárdica segura y confiable durante la cirugía cardíaca, siendo un método ideal en casos de cirugías de elevado riesgo quirúrgico.</p></abstract>
<abstract abstract-type="short" xml:lang="en"><p>lntroduction: This study reports the first experience in the use of sanguineous cardioplegia during cardiac surgery in the Mexico Hospital and exposes the important role that this procedure plays in this type of surgery. Materials and Methods: A prospective study was carried out with 200 consecutive patients programmed for different cardiac surgical procedures with the use of sanguineous cardioplegia during the period of September 1999 to February 2002. Results: Of the 200 cases 122 were male and 78 females, all with average ages of 57.48 years. Seventy one patients carne out of cardiac arrest with spontaneous rhythm. Tweive patients died and 30 cases presentes post- surgícal complications: 9 patients presentes acute myocardium infarct, 6 cases presentes Respiratory cardiac arrest, 12 had cardiac arrhythmias and 3 patients presentes congestivo cardiac insufficiency. Conclusions: in this preliminary experience the use of sanguineous cardioplegia seems to provide a safe and refiable myocardium protection during cardiac surgery, making it an ideal method in high risk surgery.</p></abstract>
<kwd-group>
<kwd>cardioplejia sanguínea</kwd>
<kwd>protección miocárdica</kwd>
<kwd>arresto cardíaco</kwd>
<kwd>sanguineous cardioplegia</kwd>
<kwd>myocardium protection</kwd>
<kwd>cardiac arrest</kwd>
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</article-meta>
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<self-uri xlink:href="http:/www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1409-41422002000300007&amp;lng=en&amp;nrm=iso&amp;tlng=en"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1409-41422002000300007&amp;lng=en&amp;nrm=iso&amp;tlng=en"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1409-41422002000300007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p>Paciente de 32 años, que ingresa a la sala de guardia por sufrir politraumatismo secundario a accidente automovilístico. Se le realiza Rx de tórax que evidencia ensanchamiento de mediastino con sospecha clínica y por estudios con TAC y ecotransesofágico de rotura de aorta torácica, confirmada por angiografía de aorta descendente que muestra una imágen compatible con pseudoaneurisma. Debido a que la paciente persiste hipotensa, se decide tratamiento inmediato por vía endovascular, colocando un stent graft expandible con balón, con resultado exitoso y sin complicaciones. En el seguimiento con TAC con contraste al mes, a los 6 meses y al año, no se observaron alteraciones de la prótesis ni leaks peri protésico o re-estenosis.</p></abstract>
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